Enclomiphene citrate is an oral medicine that studies have tested in men with secondary hypogonadism, a form of low testosterone where the testes are not getting enough signal from the brain. In those trials it raised testosterone, LH and FSH, and it kept sperm counts in the normal range, while testosterone gel did not. Approval and availability differ by country, so the sections below cover the US picture and the questions to bring to a prescriber.
What is hypogonadism?
Apollo Pharmacy’s enclomiphene page describes hypogonadism in two forms. In secondary hypogonadism, the testes can still make testosterone but do not get enough hormone signals from the brain. In primary hypogonadism, the main problem is within the testes themselves. MedlinePlus testosterone levels test page, from the U.S. National Library of Medicine, says that in men, low T can come from problems with the testicles, chronic diseases such as liver or kidney disease, a pituitary gland disorder, benign tumors, testicle injury, alcohol use disorder, or genetic conditions such as Klinefelter syndrome.
The same page lists symptoms that may point to low T: low sex drive, erectile dysfunction, infertility, enlarged breasts, lack of face or body hair, thinning bones or anemia without a known cause, and loss of muscle mass. It also says a testosterone level test alone cannot diagnose a condition. Abnormal results together with symptoms may point to a health problem.
Enclomiphene’s studies focus on secondary hypogonadism. That matters because enclomiphene raises those brain signals, so its effect depends on the testes responding, according to Apollo Pharmacy’s enclomiphene page.
What is enclomiphene, and how is it different from clomiphene?
The 2013 trial in the Journal of Sexual Medicine describes clomiphene citrate as a mixture of two forms, enclomiphene and zuclomiphene. The 2016 review in Expert Opinion on Pharmacotherapy calls enclomiphene the trans isomer of clomiphene, a non-steroidal estrogen receptor antagonist.
Blokes, which sells a product it calls Testosterone Rx (Enclomiphene), says zuclomiphene is a weaker, estrogenic form and that its isolated enclomiphene causes fewer estrogen-related effects. That is the seller’s claim, and it is the main reason the seller gives for choosing enclomiphene over clomiphene.
What the research found
2013 trial: 12 men, testosterone gel compared
The 2013 study in The Journal of Sexual Medicine was a randomized, open-label, phase IIB trial in 12 men with secondary hypogonadism who had previously used topical testosterone. It compared oral enclomiphene citrate with testosterone gel. At six months, testosterone averaged 525 ± 256 pg/dL in the enclomiphene group and 545 ± 268 pg/dL in the gel group. Sperm counts rose in seven of seven men at three months and six of six at six months on enclomiphene. The gel did not raise sperm counts above 20 × 10⁶/mL in any of five men at three months.
2016 phase III studies: overweight men, 16 weeks
The 2016 study in BJU International ran two parallel randomized, double-blind, placebo-controlled phase III studies (ZA-304 and ZA-305) in overweight men aged 18 to 60 with secondary hypogonadism, comparing two doses of enclomiphene citrate with AndroGel 1.62%. Over 16 weeks, testosterone rose in all treatment groups. FSH and LH rose in the enclomiphene groups and fell in the gel group. Enclomiphene kept sperm concentration in the normal range, while the gel group had a marked reduction in spermatogenesis.
2025 meta-analysis: clomiphene and enclomiphene pooled
The 2025 systematic review and meta-analysis in Archives of Endocrinology and Metabolism pooled randomized trials that searched up to July 2024. It covered selective estrogen receptor modulators, specifically clomiphene and enclomiphene, against placebo, testosterone gel or hCG. Compared with placebo, testosterone rose by a mean difference of 273.76 ng/dL (95% CI 191.87 to 355.66). No significant difference in total testosterone was seen between the SERM and testosterone gel groups. The authors conclude that SERM therapy “should be considered as an alternative to T gel therapy.”
2016 expert review
The 2016 review in Expert Opinion on Pharmacotherapy is an expert review, not a trial. It concludes that initial results support enclomiphene raising testosterone by increasing LH and FSH, without negatively affecting semen parameters.
How strong is the evidence, and what does it leave out?
The trials are small and short: 12 men over six months in 2013, and 16 weeks in the 2016 studies. The 2025 meta-analysis pools clomiphene with enclomiphene, so its results cover both drugs. Its heterogeneity figure for testosterone (I2 = 89%) means results varied widely between studies. The outcomes these studies measured were testosterone, LH, FSH, sperm counts, and in the 2013 trial, estradiol. Long-term safety, muscle strength and pregnancy outcomes sit outside those measures.
Does enclomiphene raise estrogen?
The 2013 trial measured estradiol among its blood markers, but the findings it reports centre on testosterone, LH, FSH and sperm counts. Blokes says its product has a lower risk of estrogen-related side effects than clomiphene and than testosterone replacement. Those are the seller’s words. Ask your prescriber to check estradiol with your blood work if estrogen effects concern you.
How risky is enclomiphene? Side effects and who should talk to a prescriber first
The side effects below come from the seller and pharmacy pages, which list them in different ways. Apollo Pharmacy describes the common effects as usually mild.
| Source | What it lists |
|---|---|
| Apollo Pharmacy, common (usually mild) | Headache; nausea or stomach discomfort; hot flushes; dizziness |
| Apollo Pharmacy FAQ | Nausea, vomiting, heavy bleeding at the initial stage, weight gain and headaches (this answer is framed around female infertility) |
| Blokes, its page’s list | Mild headaches; mood changes or irritability; temporary visual disturbances (blurriness or floaters); increased libido or changes in energy levels; mild nausea or digestive discomfort |
| Apollo Pharmacy, serious | New or sudden changes in vision; chest pain or difficulty breathing; pain, swelling, warmth or redness in one leg; swelling of the face, lips, tongue or throat. Apollo says to “consult your doctor right away.” |
Apollo’s page lists these cautions. Talk with a prescriber first if you:
- are under 18, which Apollo says is unsafe
- are pregnant or breastfeeding, where Apollo says it is not recommended or should be used with caution
- have liver disease, which Apollo says enclomiphene may worsen, or kidney disease, where it should be used with caution
- want children, since Apollo says semen testing may be considered if fertility is a concern
- drink alcohol, which Apollo says is not recommended during treatment
Apollo also says to report mood changes, and to avoid driving if you get blurred vision or dizziness.
Can enclomiphene cause weight gain?
Apollo Pharmacy’s FAQ lists weight gain among the common side effects, alongside nausea, vomiting, heavy bleeding at the initial stage and headaches. The trial abstracts list testosterone, LH, FSH and sperm counts (and in 2013 estradiol and other hormones) as outcomes and do not report weight gain. Apollo says most of these side effects resolve gradually, and to talk to your doctor if they persist or worsen.
Is it bad to take enclomiphene every day?
Apollo Pharmacy’s page says there is no single treatment duration for everyone. Your prescriber sets it from your hormone levels, symptoms, fertility goals, side effects and response. The 2013 trial ran six months, and the 2016 studies ran 16 weeks. Apollo also says not to stop abruptly without your physician’s advice. Its FAQ says it is not recommended for more than three treatment cycles, but that line sits in a section framed around female infertility, so confirm the timeframe with your prescriber.
Can you build muscle on enclomiphene?
The trials were in men with low testosterone, not in men training for muscle gain. Their outcomes were testosterone, LH, FSH and sperm counts. Blokes says full benefits, including muscle strength and metabolism changes, typically develop over six weeks. Apollo Pharmacy says strength training can support muscle strength when you have low testosterone. MedlinePlus lists loss of muscle mass among the symptoms of low T.
Does enclomiphene make you feel good?
Apollo Pharmacy says some men may notice improvements in low energy as testosterone rises, although individual responses vary. Blokes says most people begin noticing improvements in energy, mood and libido within a few weeks. Its page also quotes a customer: “After a few weeks of taking the Enclomiphene I noticed that it felt like a curtain had been lifted and I started feeling more and more like myself.” Customer quotes are the seller’s selection, not trial results, and mood changes are on the side-effect list above.
Why did the FDA not approve enclomiphene?
As of October 29, 2026, this page cannot tell you whether the FDA has approved enclomiphene, or why. To check, search the FDA’s drug records at fda.gov/drugs, or ask your prescriber or pharmacist about the status of the product where you live.
The 2016 review says the FDA has approved clomiphene citrate for ovarian dysfunction in women. Apollo Pharmacy says enclomiphene’s approval and availability vary by country, and it should be used only under medical supervision according to local prescribing requirements.
Apollo Pharmacy’s pages also disagree with each other on who the drug is for. Its enclomiphene page says it is used in the treatment of female infertility, while its other sections describe secondary hypogonadism in men, and its FAQ says it has mainly been used for secondary hypogonadism in men.
Blokes says its clomiphene and Testosterone Rx are “prescribed off-label” and not covered by insurance.
What does enclomiphene cost?
Prices as of October 29, 2026. Prices and bundles change, so check today’s price directly with the company. The figures below are Blokes’s own, from its page. No standalone price for enclomiphene citrate appears on the page. The $99 figure is the “from” price of Blokes’s Testosterone Rx subscription, a promoted offer, so the exact price must be confirmed at the seller before you pay.
| Item (as named on the page) | Price shown | What the page says |
|---|---|---|
| Testosterone Rx (Enclomiphene) monthly subscription | From $99 a month (promoted offer) | Includes all medications, clinician consults and follow-up labs; plans are billed quarterly; “No hidden fees” |
| Complete Hormone Panel (56 biomarkers) | $74.00 (regular $149.00) | Offered as a new-customer special |
| Advanced Panel (71 biomarkers) | $199.00 (regular $399.00) | Hormones, metabolism and thyroid |
| Comprehensive Panel (110 biomarkers) | $349.00 (regular $699.00) | Most in-depth health assessment |
The cart shows separate lines for an at-home blood draw fee, processing fees and shipping, without amounts. Blokes says it does not take insurance and that its lab test is HSA/FSA eligible through Flex.
How do you buy it, cancel it and get a refund?
Blokes describes its process as a lab test, then a clinician consultation to review results and set a treatment plan, then medication mailed to your door. It says the lab test is available only in certain states, and that New York and New Jersey have different lab pricing. It says its medicine comes from U.S.-based compounding pharmacies that source FDA-approved ingredients. It also says “Easy cancellations.”
The FDA warns about products sold online to boost sexual function. Its FDA health fraud warning page on tainted sexual enhancement products, captured October 5, 2026, says many such products are likely to be contaminated with hidden ingredients and calls them a type of medication health fraud. This is information, not legal advice. Buy only through a prescriber and a pharmacy you can identify, and ask for the name of the pharmacy that makes or dispenses your medicine.
Could you get the same results with a routine you do yourself?
Apollo Pharmacy lists five habits: stay physically active with strength training, get enough sleep, eat a varied diet, keep a healthy weight, and limit excess alcohol. Blokes says its product works best when paired with nutrition, training and recovery. Apollo Pharmacy says enclomiphene should be used only under medical supervision according to local prescribing requirements, and its page describes blood tests and follow-up. Whether a prescription is required where you live is a question for your prescriber or pharmacist. The studies tracked testosterone, LH, FSH and sperm over time. Doing it alone means keeping those tests and that follow-up on schedule yourself.
Before you order: a checklist
Bring to your visit:
- a list of every medicine and supplement you take, which Apollo says to share with your doctor
- your symptoms and how long you have had them
- your fertility goals, if children matter to you
Track:
- energy, mood, sleep and libido over the weeks
- any headache, nausea, dizziness or vision change
Ask:
- Is enclomiphene approved where I live, and what is its status?
- Which blood tests will you order: morning testosterone, LH, FSH, estradiol, a blood count, PSA, and semen analysis if fertility matters?
- How long will treatment last, and how will you decide when to stop?
- What is the total cost, including labs, fees and shipping?
- What is the refund window and cancellation process, in writing?
- Which pharmacy makes the medicine, and where?
By the Integrative Health Evidence Guide Team